Department of Obstetrics and Gynecology, Ospedali Riuniti di Bergamo, Bergamo, Italy.
Eur J Obstet Gynecol Reprod Biol. 2009 Dec;147(2):135-8. doi: 10.1016/j.ejogrb.2009.07.021. Epub 2009 Aug 26.
To identify women at actual risk of pre-eclampsia and poor pregnancy outcome in a selected group of high risk patients.
Prospective study of women with previous pre-eclampsia and/or intra uterine growth retardation, intra uterine death (> or =20th week), chronic hypertension, three or more previous spontaneous abortions. All subjects were followed-up till pregnancy outcome. Gestational week at delivery and birth weight were recorded. Other outcome measures were: intra uterine growth retardation, pregnancy-induced hypertension, pre-eclampsia, abruptio placenta, admission in neonatal intensive care unit.
139 patients were enrolled and followed-up until the end of pregnancy. Abnormal Doppler results at 12-14th week examination were associated with intra uterine growth retardation, fetal death/spontaneous abortion and small for gestational age birth.
This study indicates that early evaluation of arterial uterine RI and presence of notches may be predictive of low birth weight and intra uterine growth retardation in a high risk population.
在高危人群中，确定患有先兆子痫和妊娠结局不良实际风险的女性。
对有既往先兆子痫和/或宫内生长迟缓、宫内死胎（≥20 周）、慢性高血压、三次以上自发性流产史的女性进行前瞻性研究。所有受试者均随访至妊娠结局。记录分娩时的孕周和出生体重。其他结局指标包括：宫内生长迟缓、妊娠高血压、先兆子痫、胎盘早剥、新生儿重症监护病房入院。
共纳入 139 例患者，并随访至妊娠结束。12-14 周检查时的异常多普勒结果与宫内生长迟缓、胎儿死亡/自然流产和小于胎龄儿出生有关。
本研究表明，早期评估子宫动脉 RI 和切迹的存在可能有助于预测高危人群的低出生体重和宫内生长迟缓。
