Abizanda Pedro, López-Ramos Beatriz, Romero Luis, Sánchez-Jurado Pedro Manuel, León Matilde, Martín-Sebastiá Elena, López-Jiménez Esther
Geriatrics Department, Complejo Hospitalario Universitario of Albacete, Albacete, Spain.
Dement Geriatr Cogn Disord. 2009;28(2):179-86. doi: 10.1159/000235797. Epub 2009 Aug 28.
To construct and validate a mini-battery to discriminate between Alzheimer's disease (AD) and mild cognitive impairment (MCI) in patients seen at a hospital memory clinic.
In a cohort of 310 subjects (137 with MCI and 173 with AD), the area under the receiver operating curve (AUC) was used to select the neuropsychologic diagnostic test battery subtests with the best overall performance, namely, the Mini-Mental State Examination (MMSE, 0.715), Logical Memory II (LMII, 0.721), Verbal Fluency Test (0.747), and Lawton index (0.742). A mini-battery test was constructed with the following formulation: FMLL = [(Fluency Test/17 + MMSE/30 + LMII/32 + Lawton/8)/4] x 100. Another cohort of 87 subjects with MCI and 100 with AD was used to validate the mini-battery and to calculate the psychometric properties.
The concurrent validity with Reisberg's Global Deterioration Scale was r = 0.792 (p < 0.001). Cronbach's alpha internal consistency was 0.6358. The AUC to diagnose MCI or AD was 0.879 (95% CI: 0.832-0.927; p < 0.001). Specificity for MCI diagnosis was 0.9 when FMLL scores were above 59% and 1 when scores were above 76%.
The FMLL mini-examination is a useful tool to differentiate between MCI and AD in patients seen in a memory clinic.
构建并验证一个小型测试组合，用于区分在医院记忆门诊就诊的患者是患有阿尔茨海默病（AD）还是轻度认知障碍（MCI）。
在一个由310名受试者组成的队列中（137名患有MCI，173名患有AD），采用受试者工作特征曲线下面积（AUC）来选择总体表现最佳的神经心理学诊断测试组合子测试，即简易精神状态检查表（MMSE，0.715）、逻辑记忆Ⅱ（LMII，0.721）、语言流畅性测试（0.747）和劳顿指数（0.742）。用以下公式构建了一个小型测试组合：FMLL = [（语言流畅性测试/17 + MMSE/30 + LMII/32 + 劳顿指数/8）/4]×100。另一组由87名患有MCI的受试者和100名患有AD的受试者组成，用于验证该小型测试组合并计算其心理测量学特性。
与雷斯伯格总体衰退量表的同时效度为r = 0.792（p < 0.001）。克朗巴赫α内部一致性为0.6358。诊断MCI或AD的AUC为0.879（95%置信区间：0.832 - 0.927；p < 0.001）。当FMLL分数高于59%时，MCI诊断的特异性为0.9，当分数高于76%时，特异性为1。
FMLL小型检查是区分记忆门诊患者MCI和AD的有用工具。
