Remacle Marc, Lawson Georges, Hantzakos Anastasios, Jamart Jacques
Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital of Louvain at Mont-Godinne, Yvoir, Belgium.
Otolaryngol Head Neck Surg. 2009 Sep;141(3):374-81. doi: 10.1016/j.otohns.2009.06.088.
The aim of this study was to evaluate long-term results of endoscopic surgery for supraglottic carcinoma.
Case series with chart review.
Tertiary care university hospital.
From 1992 to 2004, 45 patients diagnosed with supraglottic squamous cell carcinoma (two Tis, nine T1N0, 27 T2N0, two T2N1, one T2N2, four T3N0) underwent different types of endoscopic supraglottic laryngectomies according to the European Laryngological Society (ELS) classification: three limited excision (type I); 27 medial without resection of the preepiglottic space (type IIb); one medial with resection of the preepiglottic space (type IIIa); three medial with resection of the preepiglottic space (type IIIb); nine lateral (type IVa); two lateral (type IVb).
Overall survival was 93 +/- 4 percent (SE) after three years and 89 +/- 6 percent (SE) after five years. The median follow-up is 3.7 years. Patients with clinically N0 necks were found to have positive nodes in eight (19%) cases. Two cases of postoperative hemorrhage were controlled by electrocautery. All of the patients without previous treatment for larynx cancer regained swallowing function within five days to three weeks after surgery. Mean duration of hospitalization was 12.5 days.
Endoscopic partial laryngectomies, as defined by the ELS classification, for selected supraglottic squamous cell carcinoma proved to be an excellent alternative to radiotherapy and open neck surgery.
本研究旨在评估声门上型癌内镜手术的长期效果。
病例系列研究并进行图表回顾。
三级医疗大学医院。
1992年至2004年,45例诊断为声门上型鳞状细胞癌的患者(2例Tis,9例T1N0,27例T2N0,2例T2N1,1例T2N2,4例T3N0)根据欧洲喉科学会(ELS)分类接受了不同类型的内镜声门上喉切除术:3例有限切除(I型);27例未切除会厌前间隙的内侧切除(IIb型);1例切除会厌前间隙的内侧切除(IIIa型);3例切除会厌前间隙的内侧切除(IIIb型);9例外侧切除(IVa型);2例外侧切除(IVb型)。
三年后的总生存率为93±4%(标准误),五年后的总生存率为89±6%(标准误)。中位随访时间为3.7年。临床颈部N0的患者中有8例(19%)发现有阳性淋巴结。2例术后出血通过电灼控制。所有未接受过喉癌治疗的患者在术后5天至3周内恢复了吞咽功能。平均住院时间为12.5天。
对于选定的声门上型鳞状细胞癌,ELS分类定义的内镜部分喉切除术被证明是放疗和开放性颈部手术的极佳替代方案。