Royal Institute of Technology/Philosophy, Teknikringen 78B, 10044 Stockholm, Sweden.
Regul Toxicol Pharmacol. 2009 Dec;55(3):367-71. doi: 10.1016/j.yrtph.2009.08.009. Epub 2009 Aug 29.
A significant number of Active Pharmaceutical Ingredients (APIs) have been identified in the environment and in surface waters. Data on the environmental hazards associated with these substances are emerging but are still scarce. We have compiled publicly available ecotoxicity data for APIs into a database called WikiPharma. The use of the database is free of charge. It can be accessed and updated continuously as a "wiki". The aim of WikiPharma is to provide an easily accessible, comprehensive and up-to-date overview of effects caused by pharmaceuticals on non-target organisms. The database currently contains basic information, i.e. substance name, ATC code(s) and pharmaceutical group(s), for 831 APIs representing 35 different drug classes. Effect data have been identified and included for 116 of these substances. These ecotoxicity test data have been extracted from 156 different sources. The development of a comprehensive database on ecological hazard of APIs can facilitate identification of data gaps and promote environmental risk assessment of these substances. The database is available at www.wikipharma.org.
大量的活性药物成分(APIs)已经在环境和地表水中被发现。与这些物质相关的环境危害的数据正在出现,但仍然很少。我们已经将可公开获得的 API 生态毒性数据编制成一个名为 WikiPharma 的数据库。该数据库可免费使用。它可以作为一个“维基”持续访问和更新。WikiPharma 的目的是提供一个易于访问、全面和最新的关于药物对非目标生物的影响的概述。该数据库目前包含 831 种 API 的基本信息,即物质名称、ATC 代码和药物组,代表 35 种不同的药物类别。其中 116 种物质的毒性数据已经确定并包括在内。这些生态毒性测试数据从 156 个不同的来源中提取。建立一个关于 API 生态危害的综合数据库可以促进识别数据空白,并促进对这些物质的环境风险评估。该数据库可在 www.wikipharma.org 上获取。