亚硝酸钠对牛肠系膜动脉中紫外线诱导的舒张及紫外线依赖性鸟苷酸环化酶激活的影响。

Effects of sodium nitrite on ultraviolet light-induced relaxation and ultraviolet light-dependent activation of guanylate cyclase in bovine mesenteric arteries.

作者信息

Wigilius I M, Axelsson K L, Andersson R G, Karlsson J O, Odman S

机构信息

Department of Pharmacology, Linköping University, Sweden.

出版信息

Biochem Biophys Res Commun. 1990 May 31;169(1):129-35. doi: 10.1016/0006-291x(90)91443-v.

DOI:10.1016/0006-291x(90)91443-v

PMID:1972015

Abstract

It was demonstrated that precontracted strips from different bovine mesenteric arteries showed variation in sensitivity to ultraviolet radiation (366 nm). Some strips relaxed when they were exposed to ultraviolet light, others showed no sensitivity at all and, finally, some showed contraction. However, all arteries relaxed when they were irradiated with UV-light in the presence of 10 microM NaNO2. Ultraviolet radiation (366 nm) increased the activity of guanylate cyclase in crude homogenate from bovine mesenteric arteries by about 20-fold in the presence of NaNO2, while UV-light in the absence of sodium nitrite had no effect on the guanylate cyclase activation. These results support the notion that nitrite may be essential for vascular smooth muscle relaxation by UV-light, possibly through the release of nitric oxide.

摘要

结果表明，来自不同牛肠系膜动脉的预收缩条带对紫外线辐射（366nm）的敏感性存在差异。一些条带在暴露于紫外光时会舒张，另一些则完全没有敏感性，最后，还有一些表现出收缩。然而，当在10微摩尔亚硝酸钠存在的情况下用紫外光照射时，所有动脉都会舒张。在亚硝酸钠存在的情况下，紫外线辐射（366nm）使牛肠系膜动脉粗匀浆中的鸟苷酸环化酶活性增加了约20倍，而在没有亚硝酸钠的情况下，紫外光对鸟苷酸环化酶的激活没有影响。这些结果支持了这样一种观点，即亚硝酸盐可能是紫外线使血管平滑肌舒张所必需的，可能是通过一氧化氮的释放来实现的。