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一种方便的超声促进的区域选择性合成稠合多环 4-芳基-3-甲基-4,7-二氢-1H-吡唑并[3,4-b]吡啶。

A convenient ultrasound-promoted regioselective synthesis of fused polycyclic 4-aryl-3-methyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridines.

机构信息

Department of Chemistry, Faculty of Sciences, University of Guilan, Rasht, Iran.

出版信息

Ultrason Sonochem. 2010 Feb;17(2):301-5. doi: 10.1016/j.ultsonch.2009.08.001. Epub 2009 Aug 7.

DOI:10.1016/j.ultsonch.2009.08.001
PMID:19720550
Abstract

Fused polycyclic 4-aryl-3-methyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridines were obtained in a three-component regioselective reaction of 5-amino-3-methyl-1H-pyrazole, 2H-indene-1,3-dione and arylaldehydes in ethanol under ultrasound irradiation. This rapid method produced the products in short reaction times (4-5min) and excellent yields (88-97%).

摘要

在超声辐射下，5-氨基-3-甲基-1H-吡唑、2H-茚-1,3-二酮和芳醛在乙醇中进行三组分区域选择性反应，得到了融合的多环 4-芳基-3-甲基-4,7-二氢-1H-吡唑并[3,4-b]吡啶。这种快速方法在短反应时间（4-5 分钟）内以优异的收率（88-97%）得到了产物。

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