关于一种通过配体门控离子通道测量分数钙电流的新方法。 - Suppr

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About a new method to measure fractional Ca2+ currents through ligand-gated ion channels.

作者信息

Fucile Sergio, Grassi Francesca

出版信息

J Gen Physiol. 2009 Sep;134(3):259-61; author reply 263-5. doi: 10.1085/jgp.200910222.

DOI:10.1085/jgp.200910222

PMID:19720963

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2737224/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ef/2737224/d0505349f88f/JGP_200910222_LW_Fig1.jpg

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本文引用的文献

Decremental response to high-frequency trains of acetylcholine pulses but unaltered fractional Ca2+ currents in a panel of "slow-channel syndrome" nicotinic receptor mutants.在一组“慢通道综合征”烟碱样受体突变体中，对高频乙酰胆碱脉冲序列的递减反应，但分数Ca2+电流未改变。

J Gen Physiol. 2009 Feb;133(2):151-69. doi: 10.1085/jgp.200810089.

The human adult subtype ACh receptor channel has high Ca2+ permeability and predisposes to endplate Ca2+ overloading.人类成年A型乙酰胆碱受体通道具有高钙离子通透性，易导致终板钙离子过载。

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Modulation of fetal and adult acetylcholine receptors by Ca2+ and Mg2+ at developing mouse end-plates.在发育中的小鼠终板处，Ca2+和Mg2+对胎儿及成年乙酰胆碱受体的调节作用。

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Calcium permeability increase of endplate channels in rat muscle during postnatal development.出生后发育过程中大鼠肌肉终板通道钙通透性的增加

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Quantitative measurement of calcium flux through muscle and neuronal nicotinic acetylcholine receptors.通过肌肉和神经元烟碱型乙酰胆碱受体的钙通量的定量测量。

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