Chen Qian, Kuriyama Masami, Hao Xinyu, Soeta Takahiro, Yamamoto Yasutomo, Yamada Ken-Ichi, Tomioka Kiyoshi
The Academy of Fundamental and Interdisciplinary Science, Harbin Institute of Technology, China.
Chem Pharm Bull (Tokyo). 2009 Sep;57(9):1024-7. doi: 10.1248/cpb.57.1024.
A catalytic asymmetric conjugate arylation of acyclic alpha,beta-unsaturated ketones with arylboronic acids was catalyzed by 3 mol% of chiral amidomonophosphane 1-rhodium(I) in the presence of potassium hydroxide in a mixture of 1,4-dioxane and water at 70 degrees C to afford 1,4-conjugate arylated acyclic ketones with high enantiomeric excess in high chemical yield. Thirteen examples of the reaction demonstrate the general applicability of the catalytic system.
在70℃下，于1,4 - 二氧六环和水的混合溶剂中，3 mol%的手性酰胺单膦 - 铑（I）配合物1在氢氧化钾存在下催化无环α,β - 不饱和酮与芳基硼酸的催化不对称共轭芳基化反应，以高化学产率得到具有高对映体过量的1,4 - 共轭芳基化无环酮。该反应的13个实例证明了该催化体系的普遍适用性。
