Wang Zhijuan, Li Xia
The State Key Laboratory of Plant Cell & Chromosome Engineering, Center of Agricultural Resources, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei, China.
Plant Signal Behav. 2009 Mar;4(3):165-7. doi: 10.4161/psb.4.3.7722.
The IAN (immune-associated nucleotide-binding protein) family belongs to a family of AIG1-like GTPases. These functionally uncharacterized GTP-binding proteins have unique structures and are differentially expressed in both vertebrate immune cells and plant cells during antibacterial responses. In mammals, the IANs, as a novel family of T cell receptor-responsive proteins, play critical roles in regulation of thymic development and survival of T lymphocytes through the interaction with Bcl-2 family proteins. The Arabidopsis AIG1 and AIG2, which are first identified IAN proteins, are involved in plant resistance to bacteria. Recent analysis of the expression patterns of Arabidopsis IANs suggests that these IAN proteins may play regulatory roles during plant development and response to both biotic and abiotic stress.
免疫相关核苷酸结合蛋白（IAN）家族属于一类AIG1样GTP酶。这些功能未明的GTP结合蛋白具有独特的结构，并且在脊椎动物免疫细胞和植物细胞的抗菌反应过程中差异表达。在哺乳动物中，IAN作为一类新型的T细胞受体反应蛋白，通过与Bcl-2家族蛋白相互作用，在胸腺发育调控和T淋巴细胞存活中发挥关键作用。拟南芥中的AIG1和AIG2是最早鉴定出的IAN蛋白，它们参与植物对细菌的抗性。最近对拟南芥IAN表达模式的分析表明，这些IAN蛋白可能在植物发育以及对生物和非生物胁迫的反应过程中发挥调控作用。
