埃尔莫家族构成了一组古老的肌动蛋白调节蛋白。
The Elmo family forms an ancient group of actin-regulating proteins.
作者信息
Brzostowski Joseph A, Fey Petra, Yan Jianshe, Isik Nilgun, Jin Tian
机构信息
Laboratory of Immunogenetics Imaging Facility; National Institutes of Health; Rockville, MD USA.
出版信息
Commun Integr Biol. 2009 Jul;2(4):337-40. doi: 10.4161/cib.2.4.8549.
Abstract
The Elmo protein family members are important mediators of small G protein activity, regulating actin-mediated processes such as chemotaxis and engulfment. Until recently,1 Elmo function has not been explored in professional phagocytes such as Dictyostelium discoideum. We discuss the significance of this family with respect to pathways that regulate Rac signaling, we present a comparison of Elmo proteins between representative taxa, and discuss our findings on ElmoA, one of six Elmo proteins found in D. discoideum.
摘要
埃莫（Elmo）蛋白家族成员是小G蛋白活性的重要调节因子，可调节肌动蛋白介导的过程，如趋化性和吞噬作用。直到最近，埃莫蛋白的功能在诸如盘基网柄菌等专业吞噬细胞中尚未得到研究。我们讨论了该家族在调节Rac信号通路方面的意义，对代表性分类群之间的埃莫蛋白进行了比较，并讨论了我们对盘基网柄菌中发现的六种埃莫蛋白之一埃莫A的研究结果。
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