抗自主神经膜受体抗体的存在与恰加斯病中的脑部病变不相关。
The presence of antiautonomic membrane receptor antibodies do not correlate with brain lesions in Chagas' disease.
作者信息
Py Marco O, Maciel Leonardo, Pedrosa Roberto C, Nascimento Jose H M, Medei Emiliano
机构信息
Instituto de Neurologia Deolindo Couto, Hospital Universitario, Universidade do Brasil, Rio de Janeiro, RJ, Brazil.
出版信息
Arq Neuropsiquiatr. 2009 Sep;67(3A):633-8. doi: 10.1590/s0004-282x2009000400011.
UNLABELLED
We previously demonstrated correlation between parasympathetic dysfunction and brain white matter lesions in chronic chagasic patients.
OBJECTIVE
To correlate serum functional circulating antibodies with beta adrenergic (Ab-beta), muscarinic (Ab-M) or muscarinic and beta adrenergic (Ab-Mbeta) activity, the autonomic system function and brain lesions in chronic chagasic patients.
METHOD
In fifteen consecutive chagasic patients, the autonomic nervous system was evaluated and brain magnetic resonance imaging (MRI) was performed. The sera of all patients were tested to the presence of circulating functional antibodies.
RESULTS
Sera from 11 of 15 chronic chagasic patients had some activity (Ab-beta: 7; Ab-M: 1; Ab-Mbeta: 3); however, there was no significant correlation between the presence of antibodies and the autonomic system function or the presence of hyperintensities in MRI.
CONCLUSION
The mechanism involved in the genesis of hyperintense lesions seen in brain MRI of chronic chagasic patients is still unresolved, although apparently related to parasympathetic dysfunction.
未标注
我们之前已证明慢性恰加斯病患者的副交感神经功能障碍与脑白质病变之间存在关联。
目的
将慢性恰加斯病患者的血清功能性循环抗体与β肾上腺素能（Ab-β）、毒蕈碱能（Ab-M）或毒蕈碱能和β肾上腺素能（Ab-Mβ）活性、自主神经系统功能及脑病变相关联。
方法
对15例连续的恰加斯病患者进行自主神经系统评估并进行脑磁共振成像（MRI）检查。检测所有患者血清中循环功能性抗体的存在情况。
结果
15例慢性恰加斯病患者中有11例的血清具有某些活性（Ab-β：7例；Ab-M：1例；Ab-Mβ：3例）；然而，抗体的存在与自主神经系统功能或MRI中高信号的存在之间无显著相关性。
结论
慢性恰加斯病患者脑MRI中所见高信号病变的发生机制仍未明确，尽管显然与副交感神经功能障碍有关。
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