Breen Gary H, Addante Rocco, Black Candice C
Pediatr Dent. 2009 Jul-Aug;31(4):286-8.
Hereditary gingival fibromatosis (HGF) is a rare, genetically transmitted disorder that only affects approximately 1 in 750,000 people. HGF is principally transmitted as an autosomal dominant trait. Autosomal recessive transmission has been reported infrequently in the literature. HGF primarily has its onset with the eruption of the permanent dentition, but it can also occur with the eruption of the primary dentition and can on rare occasions be present at birth. The gingival enlargement can be generalized or localized, and can vary in severity. HGF can be on isolated entity or be part of a syndrome. The purpose of this case report was to describe the early onset of nonsyndromic hereditary gingival fibromatosis in a 28-month-old who had severe generalized gingival hyperplasia. Treatment consisted of surgically uncovering 16 primary teeth. Future surgical intervention will likely be required.
遗传性牙龈纤维瘤病（HGF）是一种罕见的、遗传传递性疾病，仅影响约七十五万人中的一人。HGF主要作为常染色体显性性状传递。文献中很少报道常染色体隐性传递。HGF主要在恒牙萌出时发病，但也可在乳牙萌出时出现，极少数情况下在出生时就存在。牙龈肿大可为全身性或局限性，严重程度各异。HGF可为孤立性疾病或综合征的一部分。本病例报告的目的是描述一名28个月大患有严重全身性牙龈增生的非综合征性遗传性牙龈纤维瘤病的早期发病情况。治疗包括手术暴露16颗乳牙。未来可能需要进一步的手术干预。
