真核生物延伸因子1A2作为一种假定的癌基因。
eEF1A2 as a putative oncogene.
作者信息
Lee Mee-Hyun, Surh Young-Joon
机构信息
National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy and Cancer Research Institute, Seoul National University, Seoul, Korea.
出版信息
Ann N Y Acad Sci. 2009 Aug;1171:87-93. doi: 10.1111/j.1749-6632.2009.04909.x.
The first evidence for the role of the protein elongation factor eEF1A2 in tumorigenesis was reported by Anand and colleagues who demonstrated that eEF1A2 is overexpressed in about 30% of ovarian tumors and some established ovarian cancer cells. This abnormal expression correlates with a poor prognosis. Since this discovery, there have been several reports suggesting eEF1A2 as a diagnostic marker in various cancers. This review highlights the oncogenic potential of eEF1A2.
蛋白质延伸因子eEF1A2在肿瘤发生中作用的首个证据是由阿南德及其同事报道的，他们证明eEF1A2在约30%的卵巢肿瘤和一些已建立的卵巢癌细胞中过度表达。这种异常表达与预后不良相关。自这一发现以来，已有多篇报道提示eEF1A2可作为多种癌症的诊断标志物。本综述重点介绍了eEF1A2的致癌潜力。
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