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[严重抗组胺药中毒并发室性心动过速]

[Severe antihistamine poisoning complicated by ventricular tachycardia].

作者信息

Bastecký J, Kvasnicka J, Vortel J, Tauchman M, Wasylivová V

机构信息

I. interní klinika, Fakultní nemocnice--KUNZ, Hradec Králové.

出版信息

Vnitr Lek. 1990 Mar;36(3):266-9.

PMID:1972306
Abstract

A 26-year-old female clerk without previous heart disease ingested with suicidal intensions antihistaminic drugs--H1 blockers, astemizole (a total of 700 mg) and terfenadine (a total of 900-1200 mg). The main sign of intoxication was repeated polymorphous ventricular tachycardia type torsade de pointes, which at the onset of hospitalization changed into ventricular fibrillation. Therapeutically the impaired rhythm was controlled by electric cardioversion and atrial stimulation with a frequency of 120/min. On the third day it was possible to discontinue atrial stimulation and later the patient was discharged without any permanent sequelae.

摘要

一名26岁、既往无心脏病史的女性职员出于自杀意图服用了抗组胺药——H1阻滞剂、阿司咪唑(总量700毫克)和特非那定(总量900 - 1200毫克)。中毒的主要体征是反复出现的尖端扭转型多形性室性心动过速,在住院初期转变为心室颤动。治疗上,通过电复律和频率为120次/分钟的心房刺激控制了心律失常。第三天停用了心房刺激,之后患者出院,未留下任何永久性后遗症。

相似文献

1
[Severe antihistamine poisoning complicated by ventricular tachycardia].[严重抗组胺药中毒并发室性心动过速]
Vnitr Lek. 1990 Mar;36(3):266-9.
2
Torsade de pointes ventricular tachycardia associated with astemizole overdose.与阿司咪唑过量相关的尖端扭转型室性心动过速。
Br J Clin Pract. 1988 Jun;42(6):257-9.
3
Torsade de pointes after astemizole overdose.阿司咪唑过量服用后出现尖端扭转型室性心动过速。
Br Med J (Clin Res Ed). 1986 Mar 8;292(6521):660. doi: 10.1136/bmj.292.6521.660.
4
Astemizole-induced torsade de pointes.阿司咪唑诱发尖端扭转型室性心动过速。
Lancet. 1988 Sep 10;2(8611):624. doi: 10.1016/s0140-6736(88)90656-3.
5
A double-blind comparative trial of astemizole and terfenadine for the treatment of hay fever.
Allerg Immunol (Paris). 1989 Dec;21(10):396-8, 400.
6
Start and end of the effects of terfenadine and astemizole on histamine-induced wheals in human skin.
Acta Derm Venereol. 1989;69(3):269-71.
7
Comparative analysis of the cardiotoxicity proclivities of second generation antihistamines in an experimental model predictive of adverse clinical ECG effects.在一个可预测不良临床心电图效应的实验模型中,对第二代抗组胺药的心脏毒性倾向进行比较分析。
Arzneimittelforschung. 1996 Feb;46(2):153-8.
8
Drug-induced torsade de pointes.药物性尖端扭转型室性心动过速
Clin Pharm. 1985 Nov-Dec;4(6):675-90.
9
Giant U waves and associated ventricular tachycardia complicating astemizole overdose: successful therapy with intravenous magnesium.与阿司咪唑过量相关的巨大U波和室性心动过速:静脉注射镁治疗成功。
Am J Med. 1991 Jul;91(1):94-7. doi: 10.1016/0002-9343(91)90081-8.
10
Astemizole and terfenadine compared in hay fever.
Practitioner. 1986 Jan;230(1411):41-4.

引用本文的文献

1
Drug-Induced QT/QTc Interval Shortening: Lessons from Drug-Induced QT/QTc Prolongation.药物诱导的QT/QTc间期缩短:从药物诱导的QT/QTc间期延长中汲取的教训。
Drug Saf. 2016 Jul;39(7):647-59. doi: 10.1007/s40264-016-0411-3.
2
Possible interactions with terfenadine or astemizole.与特非那定或阿司咪唑可能存在相互作用。
West J Med. 1994 Apr;160(4):321-5.