Viola Giampietro, Salvador Alessia, Vedaldi Daniela, Dall'Acqua Francesco, Bianchi Nicoletta, Zuccato Cristina, Borgatti Monica, Lampronti Ilaria, Gambari Roberto
Department of Pharmaceutical Sciences, University of Padova, Padova, Italy.
Ann N Y Acad Sci. 2009 Aug;1171:334-44. doi: 10.1111/j.1749-6632.2009.04894.x.
In this review we summarize the structure and biological effects of linear and angular psoralens. These compounds exhibit interesting biological effects on the cell cycle, apoptosis and differentiation. These molecules should be considered promising drugs in the therapy of several diseases, including psoriasis, mycosis fungoides and cancer. Also, preclinical data demonstrate a possible use of these molecules for the treatment of beta-thalassemia and other hematological disorders.
在本综述中，我们总结了线性和角型补骨脂素的结构及生物学效应。这些化合物在细胞周期、细胞凋亡和分化方面展现出有趣的生物学效应。这些分子应被视为治疗多种疾病的有前景的药物，包括银屑病、蕈样肉芽肿和癌症。此外，临床前数据表明这些分子可能用于治疗β地中海贫血和其他血液系统疾病。
