调节中枢单胺能系统的药物对大鼠“睡眠时间”的影响。

Alterations of "sleeping time" in the rat induced by drugs which modulate central monoaminergic systems.

作者信息

Angel A, Majeed A B

机构信息

Department of Biomedical Science, University, Sheffield.

出版信息

Br J Anaesth. 1990 May;64(5):594-600. doi: 10.1093/bja/64.5.594.

DOI:10.1093/bja/64.5.594

PMID:1972333

Abstract

The effects of adrenoceptor agonists and antagonists have been determined on "sleeping time" in the rat--that is, with the animal immobile and adopting a sleeping posture. Alterations in their gross behaviour patterns were assessed also. The specific alpha 2-adrenoceptor agonists (yohimbine, WY 26393, RX 781094 and RS 21361) decreased sleeping time, as did the beta-adrenoceptor agonist clenbuterol. The specific alpha 2-adrenoceptor agonist clonidine gave a large increase in sleeping time at doses in excess of 25 micrograms kg-1. The same effect was seen with the beta-antagonist propranolol and the specific beta 2-antagonist ICI 118551.

摘要

已测定肾上腺素能受体激动剂和拮抗剂对大鼠“睡眠时间”的影响——即动物静止不动并采取睡眠姿势时的睡眠时间。还评估了它们总体行为模式的变化。特异性α2肾上腺素能受体激动剂（育亨宾、WY 26393、RX 781094和RS 21361）以及β肾上腺素能受体激动剂克仑特罗均缩短了睡眠时间。特异性α2肾上腺素能受体激动剂可乐定在剂量超过25微克/千克时可大幅延长睡眠时间。β拮抗剂普萘洛尔和特异性β2拮抗剂ICI 118551也有同样的效果。