Royal College of Surgeons in Ireland, Department of Molecular Medicine, Dublin 17, Ireland.
J Physiol. 2009 Nov 1;587(Pt 21):5039-44. doi: 10.1113/jphysiol.2009.177972. Epub 2009 Sep 1.
The intestine is an oestrogen responsive organ and circulatory oestrogens suppress Cl(-) secretion across the epithelium of the colon to promote fluid retention at the luteal stage of the menstrual cycle. Ion transporters in the colon which are involved in Cl(-) secretion show differential expression between males and females as do the signalling protein kinase intermediates involved in acutely regulating these transporters. Work from our laboratory has identified the KCNQ1/KCNE3 channel as one of the principal targets for oestrogen-induced signalling cascades in the distal colon. Through inhibition of the KCNQ1 channel, basolateral K(+) recycling is decreased so reducing the favourable electrochemical gradient for Cl(-) extrusion at the apical membrane. The actions of oestrogen on non-reproductive tissues such as the colon, kidney, lung and sweat gland will affect whole body electrolyte and fluid homeostasis and also have consequences for reproductive potential.
肠道是雌激素反应性器官，循环雌激素抑制结肠上皮细胞中的氯离子分泌，以促进月经周期黄体期的液体潴留。参与氯离子分泌的结肠离子转运体在男性和女性之间存在差异表达，参与急性调节这些转运体的信号蛋白激酶中间产物也是如此。我们实验室的工作已经确定 KCNQ1/KCNE3 通道是雌激素诱导的远端结肠信号级联反应的主要靶标之一。通过抑制 KCNQ1 通道，基底外侧钾（K+）的回收减少，从而降低了顶端膜上氯离子外排的有利电化学梯度。雌激素对非生殖组织（如结肠、肾脏、肺和汗腺）的作用将影响全身电解质和液体平衡，也会对生殖潜力产生影响。
