Tanii H, Hayashi M, Hashimoto K
Department of Hygiene, School of Medicine, Kanazawa University, Japan.
Pharmacol Biochem Behav. 1990 Jun;36(2):317-20. doi: 10.1016/0091-3057(90)90410-j.
Allylnitrile, crotononitrile and 2-pentenenitrile induce this behavioral syndrome, which includes persistent random circling, head twitching and backward running. The effects of neurotropic agents, with a selectivity for the alpha 1 or alpha 2 adrenoceptor, were examined on the nitrile-induced behavioral abnormalities. The alpha 1 agonist phenylephrine, the alpha 2 agonist clonidine and the alpha 1 antagonist prazosin, inhibited the behavioral syndrome induced by each nitrile, while the alpha 2 antagonist yohimbine had no effect. These results suggest that the noradrenergic system may be involved in the manifestation of the syndrome. Furthermore, a tonic noradrenergic influence on subcortical systems may be required for the syndrome to occur.
烯丙腈、巴豆腈和2-戊烯腈会诱发这种行为综合征，该综合征包括持续的随机转圈、头部抽搐和向后奔跑。研究了对α1或α2肾上腺素能受体具有选择性的神经营养剂对腈类诱导的行为异常的影响。α1激动剂去氧肾上腺素、α2激动剂可乐定和α1拮抗剂哌唑嗪可抑制每种腈类诱导的行为综合征，而α2拮抗剂育亨宾则没有效果。这些结果表明，去甲肾上腺素能系统可能参与了该综合征的表现。此外，该综合征的发生可能需要去甲肾上腺素能对皮质下系统的紧张性影响。
