使用 [羰基-(11)C]WAY-100635 通过正电子发射断层扫描术研究处于缓解期的双相情感障碍患者的 5-HT(1A) 受体结合情况。
5-HT(1A) receptor binding in euthymic bipolar patients using positron emission tomography with [carbonyl-(11)C]WAY-100635.
机构信息
University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK.
出版信息
J Affect Disord. 2010 Jun;123(1-3):77-80. doi: 10.1016/j.jad.2009.07.015. Epub 2009 Sep 2.
BACKGROUND
This study was undertaken to examine whether brain 5-HT(1A) receptor binding is reduced in euthymic bipolar patients.
METHODS
Eight medicated euthymic bipolar patients and 8 healthy volunteers underwent positron emission tomography scanning using the selective 5-HT(1A) receptor radioligand [carbonyl-(11)C]WAY-100635.
RESULTS
No significant difference in global postsynaptic parametric binding potential (BP(ND)) was found between euthymic bipolar patients (mean + or - SD, 4.24 + or - 0.76) and healthy volunteers (mean + or - SD, 4.34 + or - 0.86). Ninety five percent Confidence Intervals for the difference in group mean global postsynaptic BP(ND) were -0.77 to 0.97. Analysis of regional BP(ND) did not reveal regional differences between patients and healthy controls.
LIMITATIONS
The number of subjects studied was limited and all subjects were on medication.
CONCLUSIONS
In contrast to previous findings of reduced 5-HT(1A) receptor binding in untreated unipolar and bipolar depressed patients [Sargent, P.A., Kjaer, K.H., Bench, C.J., Rabiner, E.A., Messa, C., Meyer, J., Gunn, R.N., Grasby, P.M., Cowen, P.J., 2000. Brain serotonin1A receptor binding measured by positron emission tomography with [(11)C]WAY-100635: effects of depression and antidepressant treatment. Arch. Gen. Psychiatry 57, 174-180]; [Drevets, W.C., Frank, E., Price, J.C., Kupfer, D.J., Holt, D., Greer, P.J., Huang, Y., Gautier, C., Mathis, C., 1999. PET imaging of serotonin1A receptor binding in depression. Biol. Psychiatry 46, 1375-1387] and in recovered unipolar depressed patients [Bhagwagar, Z., Rabiner, E.A., Sargent, P.A., Grasby, P.M., Cowen, P.J., 2004. Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [(11)C]WAY-100635. Mol. Psychiatry 9, 386-92], this study found no difference in 5-HT(1A) receptor BP(ND) between medicated euthymic bipolar patients and healthy controls. Normal 5-HT(1A) receptor BP(ND) in these patients may be a result of drug treatment or could indicate that reduced 5-HT(1A) receptor binding is specific to the depressed state in bipolar patients.
背景
本研究旨在探究心境正常的双相障碍患者大脑 5-HT（1A）受体结合是否减少。
方法
8 名接受药物治疗的心境正常的双相障碍患者和 8 名健康志愿者接受了选择性 5-HT（1A）受体放射性配体 [羰基-(11)C]WAY-100635 的正电子发射断层扫描。
结果
心境正常的双相障碍患者（平均+或-标准差，4.24+或-0.76）和健康志愿者（平均+或-标准差，4.34+或-0.86）之间的整体突触后参数结合潜能（BP（ND））无显著差异。组间整体突触后 BP（ND）差异的 95%置信区间为-0.77 至 0.97。对 BP（ND）的区域分析未显示患者与健康对照组之间存在区域差异。
局限性
研究的受试者数量有限，所有受试者均在接受药物治疗。
结论
与未经治疗的单相和双相抑郁患者中发现的 5-HT（1A）受体结合减少的先前研究结果相反[ Sargent，P.A.，Kjaer，K.H.，Bench，C.J.，Rabiner，E.A.，Messa，C.，Meyer，J.，Gunn，R.N.，Grasby，P.M.，Cowen，P.J.，2000. 用 [(11)C]WAY-100635 通过正电子发射断层扫描测量大脑 5-羟色胺 1A 受体结合：抑郁症和抗抑郁治疗的影响。 Arch. Gen. Psychiatry 57, 174-180]; [Drevets，W.C.，Frank，E.，Price，J.C.，Kupfer，D.J.，Holt，D.，Greer，P.J.，Huang，Y.，Gautier，C.，Mathis，C.，1999. 用 [(11)C]WAY-100635 进行的抑郁症中 5-HT1A 受体结合的 PET 成像。 Biol. Psychiatry 46, 1375-1387] 和在单相抑郁恢复患者中[Bhagwagar，Z.，Rabiner，E.A.，Sargent，P.A.，Grasby，P.M.，Cowen，P.J.，2004. 用 [(11)C]WAY-100635 通过正电子发射断层扫描测量，在接受药物治疗的心境正常的双相障碍患者中发现 5-HT1A 受体结合持续减少。 Mol. Psychiatry 9, 386-92]，本研究未发现心境正常的双相障碍患者与健康对照组之间 5-HT（1A）受体 BP（ND）存在差异。这些患者中正常的 5-HT（1A）受体 BP（ND）可能是药物治疗的结果，也可能表明双相障碍患者中 5-HT（1A）受体结合减少是特定于抑郁状态的。
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