Zhang Zhi-Dan, Hu Zhi-Qi, Yi Bing
Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jun;29(6):1144-6.
To observe the histocompatibility of a polypropylene matrix implanted subcutaneously for potential hair follicle transplantation in rabbits.
The polypropylene matrix for harboring the hair follicles was prepared and implanted subcutaneously at the neck of 5 New Zealand white rabbits by means of hair follicle unit transplantation. At 1 week after the transplantation and then on a monthly basis in the following 6 months, full-thickness skin tissues were sampled at the site of grafting to evaluate the histocompatibility of the matrix material using HE staining and scanning electron microscopy.
At 1 week after implantation of the matrix material, a small number of inflammatory cells and lymphocytic infiltration were observed around the graft, with mild hyperemia in the proliferative capillaries and mild inflammatory responses. In the following 6 months, the inflammatory cells and lymphocytes around the graft decreased obviously or even disappeared, and such graft rejection responses as tissue lysis and necrosis were not observed. A large quantity of collagen fibers were found to encapsulate the polypropylene material.
Polypropylene matrix graft has good histocompatibility with the rabbit subcutaneous tissue without producing obvious graft rejection responses, suggesting its feasibility for further experiments of hair follicle transplantation.
观察皮下植入的聚丙烯基质在兔体内用于潜在毛囊移植的组织相容性。
制备用于容纳毛囊的聚丙烯基质，通过毛囊单位移植法将其皮下植入5只新西兰白兔的颈部。移植后1周，随后在接下来的6个月中每月一次，在移植部位采集全层皮肤组织，采用苏木精-伊红染色和扫描电子显微镜评估基质材料的组织相容性。
基质材料植入后1周，在移植物周围观察到少量炎性细胞和淋巴细胞浸润，增殖的毛细血管轻度充血，有轻度炎症反应。在接下来的6个月中，移植物周围的炎性细胞和淋巴细胞明显减少甚至消失，未观察到组织溶解和坏死等移植物排斥反应。发现大量胶原纤维包裹聚丙烯材料。
聚丙烯基质移植物与兔皮下组织具有良好的组织相容性，未产生明显的移植物排斥反应，表明其用于进一步毛囊移植实验的可行性。
