Lang A E
Movement Disorders Clinic, Toronto Western Hospital, Ontario, Canada.
Can J Neurol Sci. 1990 May;17(2):137-9. doi: 10.1017/s031716710003033x.
A patient with tardive dyskinesia dominated by pelvic thrusting movements is described. A retrospective review of the clinical features documented in patients with metoclopramide- and antipsychotic-induced tardive dyskinesias seen over a six year period demonstrated that the occurrence of pronounced pelvic thrusting and respiratory dyskinesias were significantly more common in the metoclopramide treated group. The occurrence of bucco-linguomasticatory movements, limb stereotypies or chorea, and mild truncal or abdominal rocking were not significantly different between the two groups. None of the tardive dystonia patients had metoclopramide as the causative agent. These findings will require confirmation in larger, better matched patient populations. Whether the differences relate to different pharmacologic profiles of drug action, patient populations exposed, or other factors, remains to be elucidated.
描述了一名以骨盆前推运动为主的迟发性运动障碍患者。对六年期间所见的甲氧氯普胺和抗精神病药物所致迟发性运动障碍患者的临床特征进行回顾性研究，结果表明，在甲氧氯普胺治疗组中，明显的骨盆前推和呼吸运动障碍的发生率显著更高。两组之间颊舌咀嚼运动、肢体刻板动作或舞蹈症以及轻度躯干或腹部摇摆的发生率无显著差异。迟发性肌张力障碍患者均无甲氧氯普胺作为致病因素。这些发现需要在更大、匹配度更好的患者群体中得到证实。这些差异是与药物作用的不同药理学特征、所接触的患者群体还是其他因素有关，仍有待阐明。
