Dufrane Denis, Gianello Pierre
Laboratory of Experimental Surgery, Université Catholique de Louvain, Faculté de Médecine, Brussels, Belgium.
Curr Opin Nephrol Hypertens. 2009 Nov;18(6):495-500. doi: 10.1097/MNH.0b013e328331a8e3.
Allogeneic islet transplantation faces difficulties because organ shortage is recurrent; several pancreas donors are often needed to treat one diabetic recipient; and the intrahepatic site of islet implantation may not be the most appropriate one. Another source of insulin-producing cells, therefore, would be of major interest, and pigs represent a possible and serious source for obtaining such cells.
Pig islet grafts may appear difficult because of the species barrier, but recent studies demonstrate that pig islets may function in diabetic primates for at least 6 months.
Pig islet xenotransplantation, however, must still overcome the selection of a suitable pig donor to translate preclinical findings into clinical applications. This review summarizes the actual acquired knowledge of pig islet transplantation in primates to select the 'ideal' pig donor.
同种异体胰岛移植面临诸多困难，因为器官短缺问题反复出现；治疗一名糖尿病受者通常需要多个胰腺供体；并且胰岛植入的肝内部位可能并非最合适的部位。因此，另一种胰岛素产生细胞来源将备受关注，而猪是获取此类细胞的一个可能且重要的来源。
由于物种屏障，猪胰岛移植可能看似困难，但近期研究表明，猪胰岛在糖尿病灵长类动物体内可发挥作用至少6个月。
然而，猪胰岛异种移植仍必须克服选择合适猪供体的问题，以便将临床前研究结果转化为临床应用。本综述总结了目前在灵长类动物中进行猪胰岛移植所获得的知识，以选择“理想”的猪供体。
