Xu Zhao-lin, Bethune Drew, Manos Daria, Foyle Annette, Henteleff Harry, Johnston Michael, Cartier Yannick
Department of Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada B3H 1V8.
Beijing Da Xue Xue Bao Yi Xue Ban. 2009 Aug 18;41(4):463-8.
To present clinical and pathologic features of pulmonary hyalnizing granuloma through analyzing three cases found in our institution and reviewing cases reported in the English language literature.
Three cases of pulmonary hyalnizing granuloma identified at our institution during the past ten years were reviewed. In the first case, the patient presented with concurrent pulmonary hyalinizing granuloma and histoplasmosis. In the second case, the patient presented with a 5.5 cm lung mass and a separate smaller lesion radiologically resembling bronchogenic carcinoma. There was very prominent polyclonal lymphocytic proliferation at the periphery especially of the smaller lesion likely representing an early stage of the disease process. In the third case, the patient presented with multiple subpleural plaque-like lesions in addition to nodular lesions of the lung. All cases also demonstrated various degrees of lymphocytic infiltration within the lesions. The English literature has been reviewed through searching the PubMed.
Since patients with pulmonary hyalinizing granuloma demonstrated a spectrum of clinical presentations, radiologic changes and histologic features with a variety of associated clinical disorders, pulmonary hyalnizing granuloma is more in keeping with a clinicopathologic entity rather than a specific pathologic disease.
通过分析我院发现的3例肺透明变性肉芽肿病例并复习英文文献报道的病例，阐述肺透明变性肉芽肿的临床和病理特征。
回顾了我院在过去十年中确诊的3例肺透明变性肉芽肿病例。第一例患者同时患有肺透明变性肉芽肿和组织胞浆菌病。第二例患者有一个5.5厘米的肺部肿块以及另一个较小的、影像学上类似支气管源性癌的病灶。在较小病灶的周边尤其有非常显著的多克隆淋巴细胞增殖，这可能代表疾病过程的早期阶段。第三例患者除肺部结节性病灶外，还有多个胸膜下斑块样病灶。所有病例在病灶内均表现出不同程度的淋巴细胞浸润。通过检索PubMed对英文文献进行了复习。
由于肺透明变性肉芽肿患者表现出一系列的临床表现、影像学改变和组织学特征，且伴有多种相关临床疾病，因此肺透明变性肉芽肿更符合一种临床病理实体，而非一种特定的病理疾病。
