Karhuvaara S, Kallio A, Koulu M, Scheinin H, Scheinin M
Department of Pharmacology, University of Turku, Finland.
Psychoneuroendocrinology. 1990;15(2):125-9. doi: 10.1016/0306-4530(90)90020-a.
The role of alpha 2-adrenoceptors in the regulation of basal prolactin secretion was investigated in healthy male volunteers. Two independent, placebo-controlled, double-blind experiments were performed. In the first experiment, 50 micrograms dexmedetomidine (MPV-1440), a selective alpha 2-adrenoceptor agonist, and saline placebo were infused (IV) in five subjects. In the second experiment, 100 mg atipamezole (MPV-1248), a selective alpha 2-adrenoceptor antagonist, and saline placebo were infused in six volunteers. The concentrations of prolactin in plasma were not affected by the drugs. These results suggest that alpha 2-adrenoceptors do not a play significant role in the control of basal prolactin secretion in healthy men.
在健康男性志愿者中研究了α2-肾上腺素能受体在基础催乳素分泌调节中的作用。进行了两项独立的、安慰剂对照的双盲实验。在第一个实验中，向五名受试者静脉注射50微克右美托咪定（MPV-1440），一种选择性α2-肾上腺素能受体激动剂，以及生理盐水安慰剂。在第二个实验中，向六名志愿者静脉注射100毫克阿替美唑（MPV-1248），一种选择性α2-肾上腺素能受体拮抗剂，以及生理盐水安慰剂。血浆中催乳素的浓度不受这些药物的影响。这些结果表明，α2-肾上腺素能受体在健康男性基础催乳素分泌的控制中不发挥重要作用。
