1999年至2006年期间，两种密切相关的耐氟康唑热带假丝酵母菌克隆株在台湾地区传播。
Two closely related fluconazole-resistant Candida tropicalis clones circulating in Taiwan from 1999 to 2006.
作者信息
Li Shu-Ying, Yang Yun-Liang, Lin Yu-Hsin, Ko Hui-Ching, Wang An-Huei, Chen Kuo-Wei, Wang Chih-Wei, Chi Hsin, Lo Hsiu-Jung
机构信息
1 Mycotic Diseases Laboratory, Research and Diagnostic Center, Centers for Disease Control , Taipei, Taiwan .
出版信息
Microb Drug Resist. 2009 Sep;15(3):205-10. doi: 10.1089/mdr.2009.0915.
Recently, we reported that diploid sequence type (DST) 140 was a predominant type of Candida tropicalis among isolates with fluconazole minimum inhibitory concentrations (MICs) >or=64 microg/ml collected in the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) in 1999. To determine if DST140 persists in Taiwan, we have used multilocus sequence typing to characterize the genetic profiles of 31 resistant isolates (MICs >or=64 microg/ml), together with 19 susceptible isolates (MICs <or=16 microg/ml) collected in TSARY 2006. Among the 50 isolates, 33 distinct DSTs were detected. Of the 31 resistant isolates, 11 (35.5%) belonged to two closely related DSTs (140 and 98), whereas none of the 19 susceptible isolates did (p = 0.004). The isolates belonging to DST140 and 98 were from different geographic regions instead of a restricted area. Thus, our data show temporal and spatial transmission of C. tropicalis clones with high fluconazole MICs in Taiwan from 1999 to 2006.
最近，我们报告称，在1999年台湾酵母菌耐药性监测（TSARY）中收集的氟康唑最低抑菌浓度（MIC）≥64μg/ml的热带念珠菌分离株中，二倍体序列类型（DST）140是主要类型。为了确定DST140在台湾是否持续存在，我们使用多位点序列分型来表征2006年TSARY中收集的31株耐药分离株（MIC≥64μg/ml）以及19株敏感分离株（MIC≤16μg/ml）的基因图谱。在这50株分离株中，检测到33种不同的DST。在31株耐药分离株中，11株（35.5%）属于两个密切相关的DST（140和98），而19株敏感分离株中均无此情况（p = 0.004）。属于DST140和98的分离株来自不同地理区域，而非局限于某一区域。因此，我们的数据显示了1999年至2006年台湾地区氟康唑MIC高的热带念珠菌克隆的时空传播情况。
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