Fyn激酶在脂质利用中的作用：AMPK活性的新上游调节因子？
Fyn kinase function in lipid utilization: a new upstream regulator of AMPK activity?
作者信息
Vatish Manu, Yamada Eijiro, Pessin Jeffrey E, Bastie Claire C
机构信息
Albert Einstein College of Medicine, Diabetes Research and Training Center, Department of Medicine, Bronx, NY 10461, USA.
出版信息
Arch Physiol Biochem. 2009 Oct;115(4):191-8. doi: 10.1080/13813450903164348.
Abstract
The balance of cellular energy levels in response to changes of nutrient availability, stress stimuli or exercise is a critical step in maintaining tissue and whole body homeostasis. Disruption of this balance is associated with various pathologies, including the metabolic syndrome. Recently, accumulating evidence has demonstrated that the AMP-activated protein kinase (AMPK) plays a central role in sensing changes in energy levels. The regulation of AMPK activity is currently the subject of significant investigation since this enzyme is a potential therapeutic target in both metabolic disorders and tumorigenesis. In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK.
摘要
细胞能量水平对营养物质可用性、应激刺激或运动变化的平衡，是维持组织和全身稳态的关键步骤。这种平衡的破坏与包括代谢综合征在内的各种病理状况相关。最近，越来越多的证据表明，AMP活化蛋白激酶（AMPK）在感知能量水平变化中起核心作用。由于该酶是代谢紊乱和肿瘤发生的潜在治疗靶点，目前AMPK活性的调节是大量研究的主题。在本综述中，我们展示了Src激酶家族成员之一Fyn与AMPK之间相互作用的新证据。
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