尿酸浓度与血压正常的孕妇的胰岛素抵抗及出生体重相关。
Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women.
作者信息
Laughon S Katherine, Catov Janet, Roberts James M
机构信息
Department of Obstetrics, Gynecology, and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
出版信息
Am J Obstet Gynecol. 2009 Dec;201(6):582.e1-6. doi: 10.1016/j.ajog.2009.06.043. Epub 2009 Sep 2.
Abstract
OBJECTIVE
We sought to investigate whether uric acid concentrations are increased in pregnant women with insulin resistance and to correlate both with fetal growth.
STUDY DESIGN
Uric acid, glucose, and insulin were measured in plasma at 20.4 (+/-2.0) weeks' gestation in 263 women. The association between uric acid and insulin resistance, as estimated using the homeostasis model assessment (HOMA), was analyzed and related to birthweights.
RESULTS
In 212 (80.6%) women who remained normotensive throughout pregnancy, HOMA increased 1.23 U per 1-mg/dL increase in uric acid (95% confidence interval, 1.07-1.42; P=.003). Infants born to normotensive women in the upper quartile of uric acid and lowest HOMA quartile weighed 435.6 g less than infants of women with highest uric acid and HOMA quartiles (P<.005).
CONCLUSION
Increasing uric acid concentrations were associated with insulin resistance in midpregnancy. Hyperuricemia was associated with lower birthweight in normotensive women, and this effect was attenuated by insulin resistance.
摘要
目的
我们试图研究胰岛素抵抗的孕妇尿酸浓度是否升高，并将两者与胎儿生长情况相关联。
研究设计
对263名女性在妊娠20.4（±2.0）周时测量其血浆中的尿酸、葡萄糖和胰岛素。分析尿酸与使用稳态模型评估（HOMA）估算的胰岛素抵抗之间的关联，并将其与出生体重相关联。
结果
在整个孕期血压正常的212名（80.6%）女性中，尿酸每增加1mg/dL，HOMA增加1.23U（95%置信区间，1.07 - 1.42；P = 0.003）。尿酸处于上四分位数且HOMA处于最低四分位数的血压正常女性所生婴儿比尿酸和HOMA处于最高四分位数的女性所生婴儿轻435.6g（P < 0.005）。
结论
孕期中期尿酸浓度升高与胰岛素抵抗相关。高血压女性中高尿酸血症与较低出生体重相关，且这种效应因胰岛素抵抗而减弱。
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