Department of Chemistry, University of New Orleans, New Orleans, LA 70148, United States.
Carbohydr Res. 2009 Nov 2;344(16):2167-72. doi: 10.1016/j.carres.2009.06.042. Epub 2009 Jul 22.
Electrospray-ionization mass spectrometric (ESIMS) studies of several A007 prodrugs in aqueous cyclomaltohexaose (alpha-cyclodextrin, alpha-CD), cyclomaltoheptaose (beta-cyclodextrin, beta-CD), and cyclomaltooctaose (gamma-cyclodextrin, gamma-CD) were performed. The acetic acid derivative of A007 should metabolize in vivo before becoming the A007 prodrug, while on the other hand, the glycine-modified A007 prodrug has surfactant-like physical properties and slowly hydrolyzed in the aqueous cyclodextrins by releasing free A007. ESIMS studies give insight into the process of prodrug hydrolysis in the presence of cyclodextrins and, hence, the influence of cyclodextrins on the timely release of the A007 prodrug. Formation of various molecular aggregates and cyclodextrin inclusion complexes of A007 prodrugs and their hydrolyzed products was demonstrated by ESIMS.
采用电喷雾电离质谱（ESIMS）研究了几种 A007 前药在水合环糊精（α-环糊精、β-环糊精和γ-环糊精）中的情况。A007 的乙酸衍生物在成为 A007 前药之前应在体内代谢，另一方面，甘氨酸修饰的 A007 前药具有表面活性剂样的物理性质，并通过释放游离的 A007 在水合环糊精中缓慢水解。ESIMS 研究深入了解了前药在环糊精存在下的水解过程，因此，环糊精对 A007 前药的及时释放有影响。ESIMS 证明了 A007 前药及其水解产物的各种分子聚集体和环糊精包合物的形成。
