Clemmons David R
Division of Endocrinology, University of North Carolina School of Medicine, hapel Hill, NC 27599-7170, USA.
Trends Endocrinol Metab. 2009 Sep;20(7):349-56. doi: 10.1016/j.tem.2009.04.002. Epub 2009 Sep 2.
The recent identification of signaling elements that regulate skeletal muscle protein balance has provided the opportunity to determine how IGF-I alters these processes. Animal studies have revealed the important role of IGF-I in preventing muscle atrophy and enabled investigators to determine the hierarchy of signaling pathways and events within each pathway that are modulated by IGF-I. These discoveries provide opportunity for future studies to target these important signaling events and develop strategies to reverse loss of muscle mass that accompanies these catabolic states. Because there are no approved medical therapies that will reverse catabolism at present, this represents an opportunity to fulfill a major unmet medical need.
近期对调节骨骼肌蛋白质平衡的信号元件的鉴定，为确定胰岛素样生长因子-I（IGF-I）如何改变这些过程提供了契机。动物研究揭示了IGF-I在预防肌肉萎缩中的重要作用，并使研究人员能够确定IGF-I所调节的信号通路及各通路内事件的层级关系。这些发现为未来的研究提供了机会，即针对这些重要的信号事件并制定策略，以逆转伴随这些分解代谢状态出现的肌肉量丢失。由于目前尚无获批的可逆转分解代谢的药物疗法，这代表了一个满足重大未满足医疗需求的契机。
