Avila Alvarez A, Marcos-Alonso S, Rueda Núñez F, Abelleira Pardeiro C
Unidad de Cardiología Infantil, Complejo Hospitalario Universitario, A Coruña, España.
An Pediatr (Barc). 2009 Nov;71(5):407-11. doi: 10.1016/j.anpedi.2009.06.028. Epub 2009 Sep 2.
After the implantation of an intracardiac device for the closure of an atrial septal defect, most centres follow the guidelines for antibiotic prophylaxis to reduce the risk of infectious endocarditis, at least during the first 6 months after the implantation, if there is no evidence of residual shunt. The aim of this report is to evaluate the knowledge, fulfillment and adherence to the recommendations of our centre on the prevention of endocarditis, of the families of patients subjected to percutaneous closure of an ASD.
We performed an observational retrospective study of 51 paediatric patients subjected to percutaneous closure of an ASD in the "Complejo Hospitalario Universitario de La Coruña", between 1999 and 2008.
A total of 51 procedures were performed, with an average of follow-up of 57.2 months. 75.7% of the families knew about the prophylaxis of endocarditis. This percentage was higher if less time had passed since the intervention and was also higher depending on the educational level of the parents. A total of 50% never stopped carrying out the endocarditis prophylaxis. In this case, a relationship was also observed, with the educational level of the parents and with the time passed since the intervention (P=0.004). The majority (73%) of the patients never had to carry out endocarditis prophylaxis.
The latest guidelines on antibiotic prophylaxis of endocarditis are increasingly restrictive in their indications in order to promote a more rational use of antibiotics. More studies are needed on the indications of antibiotic prophylaxis in endocarditis in patients with an intracardiac device, in order to establish concrete or evidence-based guidelines. Meanwhile, it is our responsibility to avoid the indiscriminate application of antibiotics, and involve the families and other health professionals.
在植入用于闭合房间隔缺损的心脏内装置后,大多数中心遵循抗生素预防指南以降低感染性心内膜炎的风险,至少在植入后的前6个月内如此,前提是没有残余分流的证据。本报告的目的是评估接受经皮闭合房间隔缺损的患者家属对我们中心预防心内膜炎建议的知晓情况、执行情况和依从性。
我们对1999年至2008年间在“拉科鲁尼亚大学综合医院”接受经皮闭合房间隔缺损的51例儿科患者进行了观察性回顾性研究。
共进行了51例手术,平均随访57.2个月。75.7%的家属了解心内膜炎的预防措施。如果自干预后时间较短,该比例较高,并且还取决于父母的教育水平。共有50%的人从未停止进行心内膜炎预防。在这种情况下,也观察到与父母的教育水平以及自干预后经过的时间之间存在关联(P = 0.004)。大多数(73%)患者从未需要进行心内膜炎预防。
关于心内膜炎抗生素预防的最新指南在其适应证方面越来越严格,以促进抗生素的更合理使用。需要对心脏内装置患者心内膜炎抗生素预防的适应证进行更多研究,以便制定具体的或基于证据的指南。同时,我们有责任避免抗生素的滥用,并让家属和其他卫生专业人员参与进来。