猪腺苷脱氨酶多态性的进一步数据及一个新等位基因的证据。

Further data on adenosine deaminase polymorphism in pigs and evidence for a new allele.

作者信息

Bigi D, Gahne B, Juneja R K

机构信息

Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala.

出版信息

Hereditas. 1990;112(1):71-6. doi: 10.1111/j.1601-5223.1990.tb00139.x.

DOI:10.1111/j.1601-5223.1990.tb00139.x

PMID:1972937

Abstract

Evidence was provided for a new erythrocyte ADA allele (Aw) in the Swedish Landrace breed of pigs. The enzyme activity of Aw variant was considerably less than that of the previously reported erythrocyte ADA variants A and B. The mobility of the Aw variant was identical to that of the A variant, both by electrophoresis and by isoelectric focusing. The in vitro heat stability (at 56 degrees C) of the Aw variant was similar to that of A and B variants. The leucocyte ADA activity was normal in pigs with the erythrocyte ADA Aw variant. The frequencies of the erythrocyte ADA alleles, A, B, Aw, and O (silent allele) in four breeds of pigs in Sweden were: Landrace--0.51, 0.19, 0.11, 0.19; Large White--0.91, 0.03, 0.0, 0.06; Duroc--0.95, 0.05, 0.0, 0.0; Hampshire--0.12, 0.14, 0.0, 0.74.

摘要

在瑞典长白猪品种中发现了一种新的红细胞腺苷脱氨酶（ADA）等位基因（Aw）。Aw变异体的酶活性明显低于先前报道的红细胞ADA变异体A和B。通过电泳和等电聚焦，Aw变异体的迁移率与A变异体相同。Aw变异体在体外（56摄氏度）的热稳定性与A和B变异体相似。具有红细胞ADA Aw变异体的猪的白细胞ADA活性正常。瑞典四个猪品种中红细胞ADA等位基因A、B、Aw和O（沉默等位基因）的频率分别为：长白猪——0.51、0.19、0.11、0.19；大白猪——0.91、0.03、0.0、0.06；杜洛克猪——0.95、0.05、0.0、0.0；汉普夏猪——0.12、0.14、0.0、0.74。