Beijing You An Hospital, Beijing, China.
Blood Purif. 2009;28(4):331-41. doi: 10.1159/000232940. Epub 2009 Sep 1.
This is the first ever decade which has witnessed the emergence of a highly lethal condition termed acute-on-chronic liver failure (ACLF), which today is the leading cause of death compared to acute and chronic liver failure. However, the complex pathophysiology of ACLF remains poorly understood. This article will attempt to summarize recent progress in the understanding of the mechanisms of cytokines in ACLF.
The search terms used on PubMed were cytokines, liver injury, complications of liver disease, and hepatic progenitor cell.
Cytokines play a significant role in the pathophysiology of ACLF including hepatocellular death, extrahepatic complications and hepatocyte regeneration. The tissue-damaging mechanisms of cytokines are closely related to their hepatocyte proliferation and regeneration function.
It remains a challenge to selectively prevent the detrimental effects of cytokines. To design interventions which selectively target the detrimental effects of cytokines, a detailed understanding of cytokines in the pathophysiology ACLF is critical.
这是首次见证一种名为慢加急性肝衰竭（ACLF）的高致死性疾病出现的十年，目前该病已成为比急性和慢性肝衰竭更常见的死亡原因。然而，ACLF 的复杂病理生理学仍未得到很好的理解。本文将尝试总结目前对细胞因子在 ACLF 中作用机制的理解方面的最新进展。
在 PubMed 上使用的搜索词为细胞因子、肝损伤、肝病并发症和肝祖细胞。
细胞因子在 ACLF 的病理生理学中起着重要作用，包括肝细胞死亡、肝外并发症和肝细胞再生。细胞因子的组织损伤机制与其促进肝细胞增殖和再生的功能密切相关。
选择性预防细胞因子的有害作用仍然是一个挑战。为了设计选择性针对细胞因子有害作用的干预措施，深入了解 ACLF 的病理生理学中细胞因子的作用至关重要。
