Copenhagen Wound Healing Center, Department of Dermatology, D42, Bispebjerg Hospital, DK-2400 Copenhagen NV, Denmark.
Curr Opin Support Palliat Care. 2009 Dec;3(4):300-4. doi: 10.1097/SPC.0b013e328331d40c.
Nonhealing wounds are a significant problem in the healthcare system all over the world. The present review focuses on some recent developments and promising clinical progresses in wound management.
New findings have increased our knowledge in several wound areas. In the treatment of wounds, the new trend in the wound device marked is to produce dressings containing compounds or drugs. This could be local antiseptics (silver, other antiseptics, honey) and pain relieving drugs such as ibuprofen and morphine. New treatments such as anti-tumor necrosis factor alfa (anti-TNFalpha) and Lactobacillus plantarum cultures have also been successfully used in hard to heal, atypical wounds. Knowledge on influencing factors as smoking and biofilm on the healing process has also been improved. Smoking results in delayed healing and increased risk of postoperative infection, whereas the role of biofilm is still at an exploratory level. Organizing models for optimal wound management are constantly being developed and refined.
Recent knowledge on the importance of new dressing materials containing active substances, new treatments for atypical wounds, influencing factors on the healing process and organization in the wound area are increasingly been launched. This may in the coming years significantly improve the treatment outcome of problem wounds.
不愈合的伤口是全世界医疗保健系统中的一个重大问题。本综述重点介绍了伤口管理方面的一些最新进展和有前途的临床进展。
新的发现增加了我们在几个伤口领域的知识。在伤口治疗中,新型伤口装置的新趋势是生产含有化合物或药物的敷料。这些化合物或药物可以是局部防腐剂(如银、其他防腐剂、蜂蜜)和止痛药,如布洛芬和吗啡。新型治疗方法,如抗肿瘤坏死因子-α(anti-TNFalpha)和植物乳杆菌培养物,也已成功用于难以愈合的非典型伤口。关于影响愈合过程的因素(如吸烟和生物膜)的知识也得到了提高。吸烟会导致愈合延迟和术后感染风险增加,而生物膜的作用仍处于探索阶段。用于优化伤口管理的组织模型也在不断开发和完善。
最近关于含有活性物质的新型敷料材料、非典型伤口的新治疗方法、愈合过程中的影响因素以及伤口区域的组织的重要性的知识不断涌现。这可能在未来几年内显著改善问题伤口的治疗效果。