人类PI基因和AACT基因的物理图谱。
A physical map of the human PI and AACT genes.
作者信息
Sefton L, Kelsey G, Kearney P, Povey S, Wolfe J
机构信息
Department of Genetics and Biometry, University College London, United Kingdom.
出版信息
Genomics. 1990 Jul;7(3):382-8. doi: 10.1016/0888-7543(90)90172-q.
We have used probes from the human genes PI, PIL, and AACT (alpha 1-antitrypsin, alpha 1-antitrypsin-related sequence, and alpha 1-antichymotrypsin) to make a pulsed-field map of the surrounding region of 14q31-32. We have discovered that the PI-PIL gene cluster is only 220 kb away from the AACT gene and that it is orientated in the opposite direction. The comparatively short distance between the genes comes as a surprise given previous estimates of the level of genetic recombination between them.
我们使用了来自人类基因PI、PIL和AACT（α1-抗胰蛋白酶、α1-抗胰蛋白酶相关序列和α1-抗糜蛋白酶）的探针，制作了14q31 - 32周围区域的脉冲场图谱。我们发现PI - PIL基因簇与AACT基因仅相距220 kb，且方向相反。鉴于之前对它们之间基因重组水平的估计，基因之间相对较短的距离令人惊讶。
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