酶促分子自组装赋予紫杉醇衍生物纳米纤维和超分子水凝胶。
Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative.
作者信息
Gao Yuan, Kuang Yi, Guo Zu-Feng, Guo Zhihong, Krauss Isaac J, Xu Bing
机构信息
Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA.
出版信息
J Am Chem Soc. 2009 Sep 30;131(38):13576-7. doi: 10.1021/ja904411z.
PMID:19731909
Abstract
By covalently connecting taxol with a motif that is prone to self-assemble, we successfully generate the precursor (5a), the hydrogelator (5b), and hydrogel of a taxol derivative without compromising the cytotoxic activity of the taxol. This approach promises a general method to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself.
摘要
通过将紫杉醇与易于自组装的基序共价连接，我们成功制备了紫杉醇衍生物的前体（5a）、水凝胶剂（5b）和水凝胶，且不影响紫杉醇的细胞毒性活性。这种方法有望成为一种通用方法，用于制备具有双重作用的治疗性分子纳米纤维，既作为递送载体又作为药物本身。
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