Huber Kathryn E, Carey Lisa A, Wazer David E
Department of Radiation Oncology, Tufts University School of Medicine, Tufts Medical Center, Boston, MA 02111, USA.
Semin Radiat Oncol. 2009 Oct;19(4):204-10. doi: 10.1016/j.semradonc.2009.05.004.
Gene expression profiling has led to the discovery of 4 distinct molecular subtypes of breast cancer: luminal A, luminal B, basal like, and HER2 enriched. Investigation of these subtypes in women with breast cancer has given insight into the heterogeneous biology and outcomes in patients with locally advanced disease. These subtypes have been found to be predictors for survival, response to systemic therapy, and locoregional recurrence. This review discusses the biology of locally advanced breast cancer and the available data on how molecular subtype may provide information regarding response to treatment and prognosis of women with locally advanced breast cancer.
基因表达谱分析已促使发现了乳腺癌的4种不同分子亚型：腔面A型、腔面B型、基底样型和HER2富集型。对乳腺癌女性患者的这些亚型进行研究，有助于深入了解局部晚期疾病患者的异质性生物学特性和预后情况。现已发现这些亚型可作为生存、对全身治疗的反应以及局部区域复发的预测指标。本综述讨论了局部晚期乳腺癌的生物学特性，以及关于分子亚型如何为局部晚期乳腺癌女性患者的治疗反应和预后提供信息的现有数据。
