兴奋性氨基酸拮抗剂6-氰基-7-硝基喹喔啉-2,3-二酮（CNQX）和3-（（±）-2-羧基哌嗪-4-基）-丙基-1-膦酸（CPP）对小鼠脊髓反射活动的不同影响。
Differential effects of the excitatory amino acid antagonists, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 3-((+-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), on spinal reflex activity in mice.
作者信息
Turski L, Bressler K, Klockgether T, Stephens D N
机构信息
Research Laboratories of Schering AG, Berlin, F.R.G.
出版信息
Neurosci Lett. 1990 May 18;113(1):66-71. doi: 10.1016/0304-3940(90)90496-v.
Intrathecal administration of the preferential quisqualate antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in anesthetized mice depressed Hoffmann (H)-reflexes, while flexor reflexes remained unaffected. The depressant effect of CNQX on H-reflexes was dose-dependent (range 0.1-10 nmol). The intrathecal administration of the selective N-methyl-d-aspartate (NMDA) antagonist 3-[(+-)-2-carboxypiperazin-4-yl]-propyl-1-phosphonate (CPP) reduced flexor reflexes (range 10-100 nmol) and had no effect on H-reflexes. These results suggest that H-reflexes in mice are mediated by spinal non-NMDA receptors, while flexor reflexes involve NMDA receptors.
在麻醉小鼠中鞘内注射优先性quisqualate拮抗剂6-氰基-7-硝基喹喔啉-2,3-二酮（CNQX）可抑制霍夫曼（H）反射，而屈肌反射不受影响。CNQX对H反射的抑制作用呈剂量依赖性（范围为0.1 - 10 nmol）。鞘内注射选择性N-甲基-D-天冬氨酸（NMDA）拮抗剂3-[(±)-2-羧基哌嗪-4-基]-丙基-1-膦酸酯（CPP）可降低屈肌反射（范围为10 - 100 nmol），对H反射无影响。这些结果表明，小鼠的H反射由脊髓非NMDA受体介导，而屈肌反射涉及NMDA受体。
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