利用限制性片段长度多态性对十个家庭中性染色体非整倍体的亲本来源进行研究。
Study of the parental origin of sexual aneuploidy in ten families using RFLPs.
作者信息
Villamar M, Fernandez E, Ayuso C, Ramos C, Benitez J
机构信息
Departemento de Genética, Fundación Jiménez Diaz, Madrid, Spain.
出版信息
Ann Genet. 1990;33(1):29-31.
PMID:1973343
Abstract
We have studied 10 families with sexual aneuploidy by means of recombinant DNA techniques. The X linked probes were F814 (DXS52), FIX (FVIII gene), pert 87.15 (DXS164), L754 (DXS84) and 47Z (DXYS5). The observed banding patterns allowed us to determine the parental origin of such aneuploidy in nine of our cases. It was paternal in seven cases and maternal in two.
摘要
我们运用重组DNA技术研究了10个患有性染色体非整倍体的家族。X连锁探针分别为F814（DXS52）、FIX（VIII因子基因）、pert 87.15（DXS164）、L754（DXS84）和47Z（DXYS5）。观察到的条带模式使我们能够确定其中9例非整倍体的亲本来源。7例为父源性，2例为母源性。
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