Van Kessel A G, Korchinski R S, Hampton C H, Laarveld B
Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada.
Domest Anim Endocrinol. 1990 Apr;7(2):217-27. doi: 10.1016/0739-7240(90)90028-x.
Absorption of somatostatin (SRIF) specific antibodies from colostrum of ewes actively immunized against SRIF may improve growth rate of the neonatal lamb by neutralizing the inhibitory effects of SRIF on pituitary and thyroid function. Growth and endocrine parameters in the offspring of SRIF immunized (SI) and control (C) crossbred ewes were examined. Lamb weight was recorded at birth and twice each week to 24 days of age. Blood samples were collected prior to first suckle and twice each week. At 21 to 24 days of age, in separate experiments, lambs were infused with glucose (0.29 g/kg), arginine (0.25 g/kg) or thyrotropin-releasing hormone (TRH; 0.33 microgram/kg). A strong correlation (R = 0.88; P less than .01) was observed between anti-SRIF titre in the ewe at parturition and in the lamb at 3 days of age. No effect on lamb birth weight (SI 4.28 +/- 0.27 kg; C 4.35 +/- 0.23 kg) was observed. At 24 days of age cumulative gain in SI lambs (5.4 +/- 0.32 kg) was greater (P less than .05) than in C lambs (4.5 +/- 0.32 kg). The growth hormone secretory responses to glucose or arginine were not affected by treatment. Plasma IGF-I, plasma thyroxine (T4) and the plasma thyrotropin and T4 responses to TRH were not different between treatments. Plasma triiodothyronine (T3) was higher (P less than .05) in SI (2.46 +/- .10 ng/ml) than in C (2.01 +/- .05 ng/ml) lambs, however, the plasma T3 response to TRH was lower in SI lambs. Plasma glucose (mg/dl) was higher (P less than .05) in SI (118.4 +/- 1.7) than in C (106.0 +/- 4.0) lambs. Plasma insulin was not affected by treatment. Increased plasma T3 and glucose concentrations during SRIF immunoneutralization in the neonate lamb may be important factors contributing to the growth response observed.
从主动免疫抗生长抑素（SRIF）的母羊初乳中吸收SRIF特异性抗体，可能通过中和SRIF对垂体和甲状腺功能的抑制作用来提高新生羔羊的生长速度。对免疫SRIF（SI）和对照（C）杂交母羊后代的生长和内分泌参数进行了检查。记录羔羊出生时的体重，并在出生后至24日龄期间每周记录两次。在首次吮乳前及之后每周采集两次血样。在21至24日龄时，在单独的实验中，给羔羊输注葡萄糖（0.29 g/kg）、精氨酸（0.25 g/kg）或促甲状腺激素释放激素（TRH；0.33微克/千克）。观察到分娩时母羊和3日龄羔羊体内抗SRIF滴度之间存在强相关性（R = 0.88；P < 0.01）。未观察到对羔羊出生体重的影响（SI组4.28±0.27千克；C组4.35±0.23千克）。在24日龄时，SI组羔羊的累积增重（5.4±0.32千克）大于（P < 0.05）C组羔羊（4.5±0.32千克）。生长激素对葡萄糖或精氨酸的分泌反应不受处理的影响。处理组之间血浆胰岛素样生长因子-I（IGF-I）、血浆甲状腺素（T4）以及血浆促甲状腺激素和T4对TRH的反应无差异。SI组羔羊的血浆三碘甲状腺原氨酸（T3）（2.46±0.10纳克/毫升）高于（P < 0.05）C组羔羊（2.01±0.05纳克/毫升），然而，SI组羔羊血浆T3对TRH的反应较低。SI组羔羊的血浆葡萄糖（毫克/分升）（118.4±1.7）高于（P < 0.05）C组羔羊（106.0±4.0）。血浆胰岛素不受处理的影响。新生羔羊SRIF免疫中和期间血浆T3和葡萄糖浓度的升高可能是导致观察到的生长反应的重要因素。
