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肠毒素性大肠杆菌对上皮细胞电阻的破坏。

Disruption of transepithelial resistance by enterotoxigenic Escherichia coli.

机构信息

Department of Veterinary Science, South Dakota State University, Brookings, SD 57007, USA.

出版信息

Vet Microbiol. 2010 Feb 24;141(1-2):115-9. doi: 10.1016/j.vetmic.2009.08.020. Epub 2009 Aug 20.

DOI:10.1016/j.vetmic.2009.08.020
PMID:19733985
Abstract

Transepithelial resistance and tight junction protein localization in porcine intestinal epithelial cells were evaluated as a function of infection with porcine enterotoxigenic Escherichia coli isolates differing in adhesin and enterotoxin profiles. Robust heat-labile enterotoxin-independent reduction of host transepithelial resistance was observed in the absence of tight junction protein mislocalization.

摘要

猪肠上皮细胞的跨上皮电阻和紧密连接蛋白定位作为感染不同粘附素和肠毒素谱的猪产肠毒素性大肠杆菌分离株的功能进行了评估。在没有紧密连接蛋白定位错误的情况下，观察到宿主跨上皮电阻的强耐热非不耐热肠毒素依赖性降低。

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