Dubey Raghvendra K, Jackson Edwin K
Clinic for Reproductive Endocrinology, Department of Obstetrics and Gynecology, Zurich Center for Integrative Human Physiology, University Hospital Zurich, Frauenklinikstrasse, Zurich, Switzerland.
Trends Endocrinol Metab. 2009 Oct;20(8):374-9. doi: 10.1016/j.tem.2009.04.007. Epub 2009 Sep 4.
2-Methoxyestradiol (2-ME) is a biologically active metabolite of 17beta-estradiol that appears to inhibit key processes associated with cell replication in vitro. The molecule has been suggested to have potent growth-inhibitory effects on proliferating cells, including smooth muscle cells and endothelial cells, and may be antiangiogenic. Because of these potential roles for 2-ME, its lack of cytotoxicity and low estrogenic activity, we hypothesize that 2-ME could be a valuable therapeutic molecule for prevention and treatment of cardiovascular diseases. Whether 2-ME is as effective in vivo as it is in vitro at modulating vascular processes remains controversial. Here we discuss recent developments regarding mechanisms by which 2-ME might regulate vascular activity and angiogenesis and speculate on the therapeutic implications of these developments.
2-甲氧基雌二醇（2-ME）是17β-雌二醇的一种生物活性代谢产物，在体外似乎能抑制与细胞复制相关的关键过程。该分子已被认为对增殖细胞，包括平滑肌细胞和内皮细胞具有强大的生长抑制作用，并且可能具有抗血管生成作用。鉴于2-ME的这些潜在作用、其缺乏细胞毒性以及低雌激素活性，我们推测2-ME可能是预防和治疗心血管疾病的一种有价值的治疗分子。2-ME在体内调节血管过程的效果是否与体外一样有效仍存在争议。在此，我们讨论关于2-ME可能调节血管活性和血管生成的机制的最新进展，并推测这些进展的治疗意义。
