Stein Wilfred D, Sanchez Cecilia P, Lanzer Michael
Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel.
Trends Parasitol. 2009 Oct;25(10):441-3. doi: 10.1016/j.pt.2009.07.003. Epub 2009 Sep 4.
Virulence and drug resistance are traits that pathogens can acquire independently, albeit these traits can influence each other. A recent publication has reported on the co-evolution of virulence and pyrimethamine resistance in malaria parasites. Here, we discuss this finding in the context of the folate biosynthesis pathway and explain how mutational changes in this pathway can affect both parasite replication rates and the development of drug resistance.
毒力和耐药性是病原体能够独立获得的特性，尽管这些特性可能相互影响。最近有一篇发表的文章报道了疟原虫中毒力和乙胺嘧啶耐药性的共同进化。在此，我们在叶酸生物合成途径的背景下讨论这一发现，并解释该途径中的突变变化如何影响寄生虫的复制率和耐药性的发展。
