DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Tuberculosis (Edinb). 2009 Nov;89(6):439-42. doi: 10.1016/j.tube.2009.08.001. Epub 2009 Sep 6.
IS6110 is a transposable element found in Mycobacterium tuberculosis complex members. Regions of preferential IS6110 integration occur within the M. tuberculosis genome but the element has not previously been shown to exhibit any sequence-specific integration preferences. Here we provide evidence for multiple independent IS6110 insertions into identical, or near-identical, positions within the highly homologous 5' region of 3 PPE genes.
IS6110 是分枝杆菌复合体成员中发现的可转移元件。IS6110 优先整合的区域发生在结核分枝杆菌基因组内，但该元件以前没有显示出任何序列特异性的整合偏好。在这里，我们提供了证据表明，多个独立的 IS6110 插入到高度同源的 3 个 PPE 基因的 5' 区域内相同或几乎相同的位置。
