铁调素表达的基因变异及其对铁代谢表型差异的影响。
Genetic variation in hepcidin expression and its implications for phenotypic differences in iron metabolism.
作者信息
Bayele Henry K, Srai Surjit Kaila S
出版信息
Haematologica. 2009 Sep;94(9):1185-8. doi: 10.3324/haematol.2009.010793.
Abstract
At the core of iron homeostasis is hepcidin, a small acute phase antimicrobial peptide that now also appears to synchronously orchestrate the response of iron transporter and regulatory genes. In this perspective article, Drs Bayele and Srai discuss cis and trans acting factors that may influence hepcidin variation in humans and their potential role in iron metabolism control. See related papers on page 1293 and 1297.
摘要
铁稳态的核心是铁调素，一种小型急性期抗菌肽，现在它似乎还能同步协调铁转运蛋白和调控基因的反应。在这篇观点文章中，贝耶勒博士和斯雷博士讨论了可能影响人类铁调素变异的顺式和反式作用因子及其在铁代谢控制中的潜在作用。见第1293页和1297页的相关论文。
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