Roufosse Florence
Haematologica. 2009 Sep;94(9):1188-93. doi: 10.3324/haematol.2009.010421.
Hypereosinophilic syndromes are a group of disorders characterized by persistent and marked hypereosinophilia not due to an underlying disease known to cause eosinophil expansion, and which is directly implicated in damage or dysfunction of at least one target organ or tissue. In this perspective article, Dr. Roufosse provides an updated classification of these disorders and discusses the recent advances in this field, including fascinating pathogenic mechanisms and novel targeted therapeutic approaches. See related paper on page 1236.
高嗜酸性粒细胞综合征是一组疾病,其特征为持续性显著嗜酸性粒细胞增多,且并非由已知可导致嗜酸性粒细胞增多的潜在疾病引起,并且这种增多直接与至少一个靶器官或组织的损伤或功能障碍相关。在这篇观点文章中,鲁福斯博士提供了这些疾病的最新分类,并讨论了该领域的最新进展,包括引人入胜的致病机制和新型靶向治疗方法。见第1236页的相关论文。