Roufosse Florence, Cogan Elie, Goldman Michel
Department of Internal Medicine, Erasme Hospital, Université Libre de Bruxelles, 808 Route de Lennik, B-1070 Brussels, Belgium.
Immunol Allergy Clin North Am. 2007 Aug;27(3):389-413. doi: 10.1016/j.iac.2007.07.002.
A large body of evidence establishing the existence of an underlying T-cell disorder in a subset of patients fulfilling hypereosinophilic syndrome (HES) diagnostic criteria has accumulated over the past decade, resulting in the definition of a novel HES variant termed "lymphocytic" HES. Although end-organ complications of hypereosinophilia are generally benign, with predominant cutaneous manifestations, long-term prognosis is overshadowed by an increased risk of developing T-cell lymphoma, as a result of malignant transformation of aberrant T cells years after HES diagnosis. Therapeutic strategies should target pathogenic T cells in addition to eosinophils, but the practical implications remain largely unexplored.
在过去十年中，大量证据表明，一部分符合高嗜酸性粒细胞综合征（HES）诊断标准的患者存在潜在的T细胞紊乱，由此定义了一种新的HES变体，称为“淋巴细胞性”HES。虽然嗜酸性粒细胞增多症的终末器官并发症一般为良性，主要表现为皮肤症状，但由于在HES诊断数年之后异常T细胞发生恶性转化，发生T细胞淋巴瘤的风险增加，这给长期预后带来了阴影。治疗策略除了针对嗜酸性粒细胞外，还应针对致病性T细胞，但实际应用方面仍 largely unexplored。 （原文最后一句中“largely unexplored”直译为“很大程度上未被探索”，结合语境意译为“在很大程度上仍未得到充分研究”更通顺，但题目要求不添加其他解释或说明，所以保留英文。）
