Department of Psychiatry, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.
World J Biol Psychiatry. 2009;10(4 Pt 2):626-8. doi: 10.1080/15622970903144004.
Poor response to antipsychotics is still an important problem in the treatment of many schizophrenia patients. N-acetylcysteine (NAC) is a compound that exerts anti-oxidant and scavenging actions against reactive oxygen species. This paper reports a case of poorly responsive schizophrenia patient who improved considerably with add-on NAC 600 mg/day. The NAC might work through activating cysteine-glutamate antiporters or reducing in nitric oxide (NO) metabolites, free radicals and cytokines or through both of these mechanisms.
抗精神病药物治疗反应不佳仍然是许多精神分裂症患者治疗中的一个重要问题。N-乙酰半胱氨酸（NAC）是一种具有抗氧化和清除活性氧作用的化合物。本文报告了一例对治疗反应不佳的精神分裂症患者，加用 NAC 600mg/天后病情明显改善。NAC 可能通过激活半胱氨酸-谷氨酸转运体或减少一氧化氮（NO）代谢物、自由基和细胞因子，或者通过这两种机制发挥作用。
