Salazar Miguel, Baskin Lyudmila, Garey Kevin W, DuPont Herbert L
St. Luke's Episcopal Hospital, TX, USA.
J Infect. 2009 Nov;59(5):303-7. doi: 10.1016/j.jinf.2009.08.019. Epub 2009 Sep 6.
Increased incidence of Clostridium difficile infection and deaths from US hospitals has occurred from 1996 to 2005.
We examined C. difficile-related mortality rates in Texas and compared results with national trends.
In Texas, there were 1004C. difficile-related deaths from 1999 to 2005 (586 (58%) attributed as the underlying cause and 418 (42%) attributed as a contributing cause). In 1999, 50 deaths were attributed as the underlying or contributing cause (0.2 per 100,000 population) versus 274 deaths in 2005 (1.2 per 100,000 population); corresponding to a 6-fold increase. There were approximately 4.5 times more hospital in-patient C. difficile-related deaths in 2005 (0.94 per 100,000) versus 1999 (0.21 per 100,000), and approximately 7 times more deaths in nursing homes in 2005 (0.14 per 100,000) than in 1999 (0.02 per 100,000).
C. difficile has become an important public health concern with a significant mortality burden on the Texas population.
1996年至2005年期间，美国医院艰难梭菌感染的发病率和死亡人数有所增加。
我们研究了德克萨斯州艰难梭菌相关的死亡率，并将结果与全国趋势进行了比较。
在德克萨斯州，1999年至2005年期间有1004例艰难梭菌相关死亡（586例（58%）归因于根本原因，418例（42%）归因于促成原因）。1999年，50例死亡归因于根本或促成原因（每10万人中有0.2例），而2005年为274例（每10万人中有1.2例）；相应增加了6倍。2005年医院住院患者中艰难梭菌相关死亡人数（每10万人中有0.94例）约为1999年（每10万人中有0.21例）的4.5倍，2005年疗养院中的死亡人数（每10万人中有0.14例）约为1999年（每10万人中有0.02例）的7倍。
艰难梭菌已成为一个重要的公共卫生问题，给德克萨斯州人口带来了重大的死亡负担。
