Sanofi Pasteur MSD, Health Economics Unit, 8 rue Jonas Salk, 69367 Lyon Cedex 07, France.
Eur J Obstet Gynecol Reprod Biol. 2009 Dec;147(2):210-4. doi: 10.1016/j.ejogrb.2009.08.011. Epub 2009 Sep 6.
Literature on the epidemiology of vulvar and vaginal cancers is scarce. The incidence of these diseases seems to be increasing. It has been reported that about 40% of vulvar and 70% of vaginal cancers may be linked to human papillomavirus (HPV). This study aimed to assess the medical burden associated with hospitalizations and management of vulvar and vaginal cancers and dysplasia (VIN and VaIN) in France.
A retrospective analysis using the French national hospital database (PMSI) was performed to assess the annual number of patients hospitalized for vulvar and vaginal cancers and VIN/VaIN, based on hospital admissions in 2006. Data for all stays and chemotherapy/radiotherapy sessions were extracted. SAE database (Statistiques annuelles des établissements de santé) was used to take into account patients who had radiotherapy sessions performed in the private sector which are not reported in the PMSI.
In 2006, 1237 and 623 patients were hospitalized for vulvar cancer and VIN, respectively. There were also 728 and 244 patients hospitalized for vaginal cancer and VaIN, respectively. Overall, about 35% of all patients were hospitalized in the private setting. For all lesions except vaginal cancer, surgery was the most common type of management. For vaginal cancer, medical care was the most prevalent (52%), followed by surgery (31%).
The burden of hospitalizations due to vulvar and vaginal cancers is substantial. Further research is needed to assess the outpatient burden due to these diseases especially for precancerous dysplasia which may be mostly managed in an outpatient setting.
外阴和阴道癌症的流行病学文献很少。这些疾病的发病率似乎在增加。据报道，大约 40%的外阴癌和 70%的阴道癌可能与人类乳头瘤病毒（HPV）有关。本研究旨在评估法国与外阴和阴道癌症及不典型增生（VIN 和 VaIN）住院治疗和管理相关的医疗负担。
使用法国国家医院数据库（PMSI）进行回顾性分析，根据 2006 年的住院情况，评估因外阴和阴道癌症及 VIN/VaIN 而住院的患者人数。提取了所有住院和化疗/放疗疗程的数据。使用 SAE 数据库（Statistiques annuelles des établissements de santé）考虑到在私人部门进行但未在 PMSI 中报告的放疗疗程的患者。
2006 年，分别有 1237 名和 623 名患者因外阴癌和 VIN 住院。还有 728 名和 244 名患者因阴道癌和 VaIN 住院。总体而言，约 35%的患者在私人机构住院。除阴道癌外，所有病变的主要治疗方法都是手术。对于阴道癌，医疗护理最为常见（52%），其次是手术（31%）。
外阴和阴道癌症导致的住院负担相当大。需要进一步研究来评估这些疾病的门诊负担，特别是对于可能主要在门诊治疗的癌前不典型增生。
