Magaña J J, Gálvez-Rosas A, González-Huerta C, Duarte-Salazár C, Lara-Alvarado L, Soria-Bastida M A, Cortés-González S, Miranda-Duarte A
Department of Genetics, National Rehabilitation Institute, Mexico City, Mexico.
Knee. 2010 Mar;17(2):157-60. doi: 10.1016/j.knee.2009.08.006. Epub 2009 Sep 6.
Osteoarthritis (OA) is the most common form of destructive joint disease that is characterized by the degeneration of the articular cartilage, synovial membrane, joint capsule, and subchondral bone. The knee is a joint commonly affected for OA. Calcitonin (CT) has been suggested to have chondroprotective effects; therefore, could play a role in the pathogenesis of OA of the knee. Genetic variations in or adjacent to the CT gene may be associated with primary OA development. We conducted a case-control association study in which we examined the correlation between a dinucleotide (cytosine-adenine, CA) repeat polymorphism at the CT locus and OA of the knee in 88 patients with OA and in 111 control subjects from the Mexican mestizo population. Allele A and genotype AG frequencies were significantly higher in patients with OA than in control subjects (56.3 vs. 43.2%; p<0.001 and 40.9 vs. 26.1%; p=0.027, respectively), and were associated with the presence of OA of the knee (odds ratio [OR], 2.62; 95% confidence interval [95% CI], 1.30-5.27, and OR, 1.93; 95% CI, 1.04-3.58, respectively) using a logistic regression model adjusted for gender, age and Body mass index (BMI). The GG genotype was associated with a lower risk of OA development of the knee; thus, it may constitute a protective factor against this disease (OR, 0.40; 95% CI, 0.16-0.98). In summary, we conclude that the dinucleotide CA polymorphism in the CT gene may become a useful marker for genetic studies of OA of the knee in Mexican population.
骨关节炎（OA）是最常见的破坏性关节疾病形式，其特征是关节软骨、滑膜、关节囊和软骨下骨的退变。膝关节是OA常累及的关节。降钙素（CT）已被认为具有软骨保护作用；因此，可能在膝关节OA的发病机制中发挥作用。CT基因内部或其附近的基因变异可能与原发性OA的发生有关。我们进行了一项病例对照关联研究，在来自墨西哥混血人群的88例OA患者和111例对照受试者中，检测了CT基因座处二核苷酸（胞嘧啶 - 腺嘌呤，CA）重复多态性与膝关节OA之间的相关性。OA患者的等位基因A和基因型AG频率显著高于对照受试者（分别为56.3%对43.2%；p<0.001和40.9%对26.1%；p = 0.027），并且使用针对性别、年龄和体重指数（BMI）进行调整的逻辑回归模型分析，它们与膝关节OA的存在相关（优势比[OR]分别为2.62；95%置信区间[95%CI]为1.30 - 5.27，以及OR为1.93；95%CI为1.04 - 3.58）。GG基因型与膝关节OA发生风险较低相关；因此，它可能构成针对这种疾病的保护因素（OR为0.40；95%CI为0.16 - 0.98）。总之，我们得出结论，CT基因中的二核苷酸CA多态性可能成为墨西哥人群膝关节OA遗传研究的有用标志物。
